苏公网安备 32100302010246号
We designed the Transposable Element ENrichment Analyzer (TEENA), which is an integrated web server to streamline transposable element enrichment analysis in various model and non-model organisms. It implements an optimized pipeline, hosts the genome/gene/TE annotations of almost one hundred species, and provides multiple parameters to enable its flexibility. Please have a try.
How the PcG protein binding and chromatin loops mediated by PREs at the ON and OFF transcription state differ? Find it out from our collaborative paper with Judith Kassis's lab and Pedro Rocha's lab from NIH/NICHD.
Our paper identified dozens of TE families overrepresented with CTCF binding sites, including LTR22_SS, LTR15_SS and LTR16_SSc which are pig-specific families ERVs.
Our collaborative paper with Kassis's lab (NIH) and Chetverina's lab (Russian Academy of Sciences) identified Crol as novel regulator of PRE-mediated repression and Polycomb recruitment.
Our collaborative paper with Cao's lab from Xiemen University uncovered the essential roles of ERV-derived enhancers for human trophoblast syncytialization.
As a followed up study of our previous MBE paper, we further uncovered how numerous ERV-derived enhancers in human TSCs are bound and regulated by the core trophoblast TFs GATA2/3 and MSX2.
Our collaborative paper with Todd Macfarlan's lab from NIH/NICHD identified numerous lineage-specific human placental enhancers and found they highly overlap with specific ERV families, including MER21A, MER41A/B, and MER39B that were previously linked to immune response and placental function.